Relationship between membrane properties and cell size of developing rat genioglossal motoneurons studied in vitro.
نویسندگان
چکیده
Electrical properties and morphology of 21 genioglossal motoneurons were measured in a slice preparation of the rat brainstem at four different postnatal ages. The motoneurons labeled with neurobiotin were reconstructed and quantified in three-dimensional space. There was no strong correlation found between the input resistance or membrane time constant and the total membrane surface area. We conclude that there is no electrical property of these developing motoneurons that can accurately predict their anatomical size.
منابع مشابه
Morphology of developing rat genioglossal motoneurons studied in vitro: relative changes in diameter and surface area of somata and dendrites.
This study describes the postnatal change in size of motoneurons in the hypoglossal nucleus that innervate the genioglossus muscle. Such anatomical information is essential for determining the cellular mechanisms responsible for the changes observed in the electrical properties of these motoneurons during postnatal development. The cells analyzed here are part of an earlier study (Núñez-Abades ...
متن کاملAnatomical and electrotonic coupling in developing genioglossal motoneurons of the rat.
Dye-, tracer- and electrotonic coupling were studied independently in genioglossal (GG) motoneurons using intracellular recordings in in vitro brainstem slices from rats postnatal ages 1-30 days. The subpopulation of GG motoneurons were retrogradely labeled after an injection of dextran-rhodamine into the posterior tongue. Dye-coupling was studied with Lucifer yellow injected into 55 motoneuron...
متن کاملTime Course of Axotomy-induced Changes in Synaptophysin Pattern and Synaptic Reaction of Spinal Motoneurons in Adult Rat
Background and Objective: Evaluation of degenerative changes of motoneurons and their related synapses can be useful in understanding the mechanisms of neurodegenerative diseases and their potential treatment. The present electron microscopic and immunohistochemical study investigates the axotomy-induced...
متن کاملTime-dependent changes in input resistance of rat hypoglossal motoneurons associated with whole-cell recording.
The effect of cellular dialysis associated with whole-cell recording was studied in 24 developing hypoglossal motoneurons in a rat brainstem slice preparation. In all cases, establishing whole-cell continuity with the electrode solution resulted in an increase in the input resistance measured in current clamp. The mean magnitude of this increase was 39.7% and the time course of the maximum effe...
متن کاملChanges during the postnatal development in physiological and anatomical characteristics of rat motoneurons studied in vitro.
The postnatal maturation of rat brainstem (oculomotor and hypoglossal nuclei) and spinal motoneurons, based on data collected from in vitro studies, is reviewed here. Membrane input resistance diminishes with age, but to a greater extent for hypoglossal than for oculomotor motoneurons. The time constant of the membrane diminishes with age in a similar fashion for both oculomotor and hypoglossal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Neuroscience letters
دوره 223 1 شماره
صفحات -
تاریخ انتشار 1997